Based on the DEFORM-3D finite element software, a temperature field model of the large casting billet was established for the problem of uneven heat transfer from the surface to the core during the heating process of the large casting billet of GH4169 alloy. The influence of heating process parameters on the internal heat transfer characteristics and temperature field distribution law of the alloy was studied. The simulation results show that the comprehensive heat transfer coefficients of different surfaces have a significant impact on the heat transfer efficiency. For the comprehensive heat transfer coefficients of surfaces with different fixed values, as the comprehensive heat transfer coefficients of the surfaces increase, the heat transfer efficiency from the surface to the core is significantly improved. For the variable surface comprehensive heat transfer coefficients, the cross-sectional temperature difference is relatively small, the heat transfer efficiency from the surface to the core is relatively low, but the heat transfer process is relatively uniform. In order to study the variation law of grain size of GH4169 alloy during the heating process, GH4169 alloy samples were prepared, and multiple sets of heat treatment tests were systematically carried out. The microstructure and the evolution law of grain structure after heat treatment were analyzed through metallographic observation. The test results showed that after multiple sets of heat treatment, the grains of the surface microstructure of the material showed a significant coarsening phenomenon. The specific manifestations are as follows: When heat-treated below 1 000 ℃, the grains show a slow growth trend. The longer the holding time, the more obvious the grain growth, with a size range of 3~8 μm. When heat-treated above 1 100 ℃, the grains show a significant coarsening trend, and the size increases to 75~100 μm. With the extension of the holding time, the growth of the grain structure gradually slows down.